Journal article
Upgrade in Gleason score between prostate biopsies and pathology following radical prostatectomy significantly impacts upon the risk of biochemical recurrence
NM Corcoran, MKH Hong, RG Casey, A Hurtado-Coll, J Peters, L Harewood, SL Goldenberg, CM Hovens, AJ Costello, ME Gleave
BJU International | Published : 2011
Abstract
Study Type - Prognosis (retrospective cohort) Level of Evidence 2b OBJECTIVE To determine the effect of an upgrade in Gleason score between initial prostate biopsy and final prostatectomy specimen on the risk of postoperative biochemical recurrence. PATIENTS AND METHODS A total of 1629 patients with paired biopsy and radical prostatectomy histology were identified from two prospectively recorded prostate cancer databases. Information on key clinical and pathological characteristics as well as prostate-specific antigen follow-up was recorded. Patients who experienced an upgrade in their Gleason score were compared with corresponding patients with concordant tumours of the lower and higher gra..
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Funding Acknowledgements
None declared. Source of Funding: departmental. NML is the recipient of the Hugh Johnston Travelling Fellowship from The Royal Australasian College of Surgeons, as well as a Urological Society of Australia and New Zealand travel grant.