Journal article
Intestinal epithelial-specific PTEN inactivation results in tumor formation
DS Byun, N Ahmed, S Nasser, J Shin, S Al-Obaidi, S Goel, GA Corner, AJ Wilson, DJ Flanagan, DS Williams, LH Augenlicht, E Vincan, JM Mariadason
American Journal of Physiology Gastrointestinal and Liver Physiology | Published : 2011
Abstract
Intestinal epithelial-specific PTEN inactivation results in tumor formation. Am J Physiol Gastrointest Liver Physiol 301: G856-G864, 2011. First published August 11, 2011; doi:10.1152/ajpgi.00178.2011.-Phosphates and tensin homolog deleted on chromosome 10 (PTEN) is a negative regulator of phosphatidylinositol 3-kinase (PI3K) signaling that is frequently inactivated in colorectal cancer through mutation, loss of heterozygosis, or epigenetic mechanisms. The aim of this study was to determine the effect of intestinal-specific PTEN inactivation on intestinal epithelial homeostasis and tumor genesis. PTEN was deleted specifically in the intestinal epithelium, by crossing PTEN Lox/Lox mice with v..
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Awarded by National Cancer Institute
Funding Acknowledgements
These studies were supported by National Cancer Institute Grants CA-123316, CA-100823, and CA-88104 and National Health and Medical Research Council of Australia Project Grant ID 566679. J. M. Mariadason is supported by a Future Fellowship from the Australian Research Council.