Journal article

Intestinal epithelial-specific PTEN inactivation results in tumor formation

Do-Sun Byun, Naseem Ahmed, Shannon Nasser, Joongho Shin, Sheren Al-Obaidi, Sanjay Goel, Georgia A Corner, Andrew J Wilson, Dustin J Flanagan, David S Williams, Leonard H Augenlicht, Elizabeth Vincan, John M Mariadason

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2011

Abstract

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a negative regulator of phosphatidylinositol 3-kinase (PI3K) signaling that is frequently inactivated in colorectal cancer through mutation, loss of heterozygosity, or epigenetic mechanisms. The aim of this study was to determine the effect of intestinal-specific PTEN inactivation on intestinal epithelial homeostasis and tumorigenesis. PTEN was deleted specifically in the intestinal epithelium, by crossing PTEN(Lox/Lox) mice with villin(Cre) mice. PTEN was robustly expressed in the intestinal epithelium and maximally in the differentiated cell compartment. Targeted inactivation of PTEN in the intestinal epithelium of PTEN(Lox/..

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University of Melbourne Researchers

Grants

Awarded by National Cancer Institute


Awarded by National Health and Medical Research Council of Australia


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

These studies were supported by National Cancer Institute Grants CA-123316, CA-100823, and CA-88104 and National Health and Medical Research Council of Australia Project Grant ID 566679. J. M. Mariadason is supported by a Future Fellowship from the Australian Research Council.