Journal article
Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study
AC Cheng, T Kotsimbos, HA Kelly, LB Irving, SD Bowler, SGA Brown, M Holmes, CR Jenkins, P Thompson, G Simpson, R Wood-Baker, SN Senanayake, SJ Brady, DL Paterson, PA Wark, JW Upham, TM Korman, DE Dwyer, GW Waterer, PM Kelly
Vaccine | ELSEVIER SCI LTD | Published : 2011
Abstract
We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls;..
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Funding Acknowledgements
AC has received research funding to perform an investigator-initiated study of influenza vaccine safety from CSL Ltd. SB has received speaker/advisory board fees or travel grants from Astra Zeneca, GSK, and Novartis. DP is on the advisory boards for Merck, AstraZeneca, Leo Pharmaceuticals, Pfizer and Johnson and Johnson; speakers bureau of AstraZeneca, Johnson and Johnson and BioMerieux. Funding: The Australian Government Department of Health and Ageing provided funding for this study via an extension to a National Health and Medical Research Council grant. ACC was funded by a NHMRC Health Professionals Fellowship and PMK by a NHMRC Career Development Award. The funder had input into the data collection instruments as it was based on a public health surveillance system but had no role in the analysis, the writing of the article or decision to publish this paper.