Journal article
Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes
KA Price, PJ Crouch, I Volitakis, BM Paterson, S Lim, PS Donnelly, AR White
Inorganic Chemistry | Published : 2011
DOI: 10.1021/ic201334q
Abstract
Copper (Cu) bis(thiosemicarbazonato) metal complexes [Cu II(btsc)s] have unique tumor-imaging and treatment properties and more recently have revealed potent neuroprotective actions in animal and cell models of neurodegeneration. However, despite the continued development of Cu II(btsc)s as potential therapeutics or diagnostic agents, little is known of the mechanisms involved in cell uptake, subcellular trafficking, and efflux of this family of compounds. Because of their high lipophilicity, it has been assumed that cellular accumulation is through passive diffusion, although this has not been analyzed in detail. The role of efflux pathways in cell homeostasis of the complexes is also large..
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Funding Acknowledgements
This work was supported by funding from the National Health and Medical Research Council of Australia and the Australian Research Council of Australia. We thank Prof. James Camakaris, Department of Genetics, The University of Melbourne, Melbourne, Australia, for his valuable suggestions and input into this work We also thank Dr, Sharon La Fontaine, Deakin University, Victoria, Australia, for Ctrl fibroblasts and Dr. Roxana Llanos and Kenny Tran of Deakin University, Victoria, Australia, for assistance with AAS.