Gallium-68 Complex of a Macrobicyclic Cage Amine Chelator Tethered to Two Integrin-Targeting Peptides for Diagnostic Tumor Imaging

Michelle T Ma; Oliver C Neels; Delphine Denoyer; Peter Roselt; John A Karas; Denis B Scanlon; Jonathan M White; Rodney J Hicks; Paul S Donnelly

Journal article

Gallium-68 Complex of a Macrobicyclic Cage Amine Chelator Tethered to Two Integrin-Targeting Peptides for Diagnostic Tumor Imaging

Michelle T Ma, Oliver C Neels, Delphine Denoyer, Peter Roselt, John A Karas, Denis B Scanlon, Jonathan M White, Rodney J Hicks, Paul S Donnelly

Bioconjugate Chemistry | AMER CHEMICAL SOC | Published : 2011

DOI: 10.1021/bc200319q

University of Melbourne Researchers

John Karas Author Pharmacology and Therapeutics

Jonathan White Author Chemistry

Rodney Hicks Author Medicine - St Vincent's Hospital

Paul Donnelly Author Chemistry

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X-Ray Molecular Structure Elucidation Facility (Msef)

X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analyt..

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Funding Acknowledgements

M.T.M. acknowledges Cancer Council Victoria for providing a Sydney Parker Smith Postdoctoral Cancer Research Fellowship; a Kaye Merlin Brutton Bequest. P.S.D. acknowledges funding from the Australian Research Council and National Health and Medical Research Council. The authors thank Dr. N. Pouliot from the Metastasis Research Lab at The Peter MacCallum Cancer Centre for gifting 66cl4 beta 3 and 66c14pBabe cells, Dr. Peter Eu for helpful discussions, Mr. Wayne Noonan for assistance with HPLC, Mr. David Muller from the Cancer Epidemiology Centre, Cancer Council Victoria for statistical analyses, and Dr. Brett Paterson for proof reading the manuscript.