Journal article
Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: A case-control study from Malawi
AL Conroy, WC Liles, ME Molyneux, SJ Rogerson, KC Kain
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Background: Because of its propensity to sequester in the placental intervillous space, Plasmodium falciparum can evade detection by peripheral smear in women with placental malaria (PM). We evaluated host biomarkers as potential indicators of occult PM infections. Methods and Findings: Using a case-control design, we evaluated the ability of biomarkers to identify PM in the absence of circulating peripheral parasites (n = 24) compared to placental smear-negative controls (n = 326). We measured levels of biomarkers (C3a, C5a, CRP, angiopoietin-1, angiopoietin-2, sTie-2, sEndoglin, VEGF, sFlt-1, tissue factor, and leptin) in maternal peripheral plasma at delivery. Using ROC curve analysis, we..
View full abstractGrants
Awarded by Canadian Institutes of Health Research
Funding Acknowledgements
This study was supported by the Canadian Institutes of Health Research grants MOP-13721 and MOP-115160 (KCK), Genome Canada through a grant by the Ontario Genomics Institute (KCK), and CIHR Canada Research Chairs (KCK, WCL). ALC was supported by a CIHR PhD studentship. SJR was supported by a Wellcome Trust Senior Research Fellowship. The funding agencies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.