Journal article

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

Hyungsoo Kim, Maria C Scimia, Deepti Wilkinson, Ramon D Trelles, Malcolm R Wood, David Bowtell, Andrew Dillin, Mark Mercola, Ze'ev A Ronai

Molecular Cell | CELL PRESS | Published : 2011

Grants

Awarded by National Cancel Institute (NCI)


Awarded by National Heart, Lung, and Blood Institute (NHLBI)


Awarded by California Institute for Regenerative Medicine


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES


Funding Acknowledgements

We thank Drs. Peter Ratcliffe (University of Oxford, UK), Craig Blackstone (National Institute of Neurological Disorders and Stroke [NINDS], National Institutes of Health [NIH]), David Chan (Caltech), and Olexander Korchynsky (University of Amsterdam) for generous gifts of DNA constructs and antibodies; Randall Johnson (University of California, San Diego) for HIF1 alpha MEFs, and Ed Monosov (Sanford-Burnham Medical Research Institute) for assistance with electron microscopy. We thank members of the Ronai lab for discussions and Dr. Susan Taylor for critical comments. This work was supported by National Cancel Institute (NCI) grants CA1111515 and CA128814 (to Z.A.R.) and by National Heart, Lung, and Blood Institute (NHLBI) grants HL088266 and HL098053 and California Institute for Regenerative Medicine RC1-00132-1 (to M.M.). M.C.S. is a California Institute for Regenerative Medicine (CIRM) clinical fellow.