Journal article

The Neurophysiology and Pathology of Brain Zinc

Stefano L Sensi, Pierre Paoletti, Jae-Young Koh, Elias Aizenman, Ashley I Bush, Michal Hershfinkel

JOURNAL OF NEUROSCIENCE | SOC NEUROSCIENCE | Published : 2011

Abstract

Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including strok..

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Grants

Awarded by National Research Foundation of Korea


Awarded by NIH


Awarded by US-Israel Binational Science Foundation


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

S.L.S. is supported by funds from the Italian Department of Education (FIRB 2003, PRIN 2006). P. P. is supported by Agence Nationale de la Recherche and FRM (Fondation pour la Recherche Medicale; "Equipe FRM" grant). J.Y.K. is supported by a National Research Foundation of Korea grant (2005-0093836). A.I.B. is supported with funds from the National Health and Medical Research Council of Australia, and The Australian Research Council. E.A. is supported by NIH Grant NS043277. E.A. and M.H. are jointly supported by a grant from the US-Israel Binational Science Foundation (2007112). We are in debt to Mary Evangeline Oberschlake for the editing and critical revision of the manuscript.