Journal article
The orexin1 receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats
B Jupp, B Krivdic, E Krstew, AJ Lawrence
Brain Research | ELSEVIER | Published : 2011
Abstract
A role for orexin A in mediating the primary and conditioned reinforcing effects of alcohol has been established. It is unclear however whether the contribution of orexins to alcohol reward occurs independently of effects on appetite and feeding, and whether orexins regulate the motivation to consume alcohol compared to other rewards. To examine this further here we investigate the effect of the orexin1 receptor antagonist, SB-334867, on self-administration of alcohol (10% v/v) under both fixed (FR) and progressive ratio (PR) schedules of reinforcement, and whether this differs from the motivation to administer a natural food reward, sucrose (0.2-0.7% w/v) in alcohol preferring (iP) rats. SB..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
These studies were funded by the National Health and Medical Research Council of Australia (project grant 508976) of which AJL is a Senior Fellow (454303); the Pratt and Besen Foundations and the Victorian Government's Operational Infrastructure Support Program.