Journal article
Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway
X Zhang, CC Milton, CLC Poon, W Hong, KF Harvey
Cell Death and Differentiation | NATURE PUBLISHING GROUP | Published : 2011
DOI: 10.1038/cdd.2011.6
Abstract
The Salvador-Warts-Hippo (SWH) pathway is a key controller of tissue growth in both flies and mammals, and deregulation of pathway activity contributes to tumour formation. The SWH pathway regulates cell growth, proliferation and apoptosis by restricting activity of the Yorkie transcriptional co-activator protein. The proteins that function together with Yorkie to drive transcription and tissue growth are beginning to be revealed and include the Scalloped (Sd), Teashirt (Tsh) and Homothorax (Hth) transcription factors. In this study, we define Wbp2 as a promoter of Yorkie-dependent growth of Drosophila melanogaster tissues. Mammalian WBP2 was previously identified as a protein that interacts..
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Funding Acknowledgements
We thank N Albanese for technical assistance, A Brumby, S Cohen, I Hariharan, J Jiang, L Luo, D Pan, H Richardson, A Zider, the Developmental Studies Hybridoma Bank, the Drosophila Genomics Resource Center, the Vienna Drosophila RNAi Center, the Australian Drosophila Research Support Facility (http://www.ozdros.com) and the Bloomington Stock Centre for fly stocks, plasmids and antibodies. KH is a Sylvia and Charles Viertel Senior Medical Research Fellow. This work was supported by a Project Grant from the National Health and Medical Research Council of Australia and a Discovery Grant from the Australian Research Council.