Journal article
Genetic male infertility and mutation of CATSPER ion channels
MS Hildebrand, MR Avenarius, M Fellous, Y Zhang, NC Meyer, J Auer, C Serres, K Kahrizi, H Najmabadi, JS Beckmann, RJH Smith
European Journal of Human Genetics | SPRINGERNATURE | Published : 2010
Abstract
A clinically significant proportion of couples experience difficulty in conceiving a child. In about half of these cases male infertility is the cause and often genetic factors are involved. Despite advances in clinical diagnostics 50% of male infertility cases remain idiopathic. Based on this, further analysis of infertile males is required to identify new genetic factors involved in male infertility. This review focuses on cation channel of sperm (CATSPER)-related male infertility. It is based on PubMed literature searches using the keywords CATSPER, male infertility, male contraception, immunocontraception and pharmacologic contraception (publication dates from January 1979 to December 20..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
R Smith is the Sterba Hearing Research Professor, University of Iowa College of Medicine, supported financially by NIH grants RO1 DC03544, RO1 DC02842 and RO1 DK074409. M Hildebrand was supported by an Australian National Health and Medical Research (NHMRC) Postdoctoral Training Fellowship.