Journal article

Towards cytoprotection in the peritransplant period

Dusan Hanidziar, Maria Koulmanda

SEMINARS IN IMMUNOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2011

Abstract

As a consequence of ischemia-reperfusion injury of whole organ transplants and hypoxia-anoxia of cell transplants, transplantation unavoidably triggers adverse, cytodestructive inflammation within the allograft. Interventions that dampen adverse inflammation may limit the extent and duration of this injury, and preserve tissue function. Moreover, these interventions should create a milieu that guides many donor-activated T cells into a tissue-protective phenotype, thus promoting graft acceptance or even tolerance. Hence, it is useful, maybe crucial, to identify the measures that minimize deleterious consequences of acute and chronic inflammation upon allograft. Several therapies that inhibit..

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University of Melbourne Researchers

Grants

Awarded by NIH


Awarded by JDRF


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

Dr. Maria Koulmanda has received grant support from NIH (PPG U19 DK080652, PO1 AI073748 and PO1 AI041521) and JDRF (4-2004-368 and 1-2007-524).