Journal article

Frontotemporal dementia as a frontostriatal disorder: Neostriatal morphology as a biomarker and structural basis for an endophenotype

Jeffrey CL Looi, Mark Walterfang, Dennis Velakoulis, Matthew D Macfarlane, Leif Anders Svensson, Lars-Olof Wahlund

Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2012


OBJECTIVE: This article reviews the evidence for a re-conceptualisation of a subtype of frontotemporal lobar degeneration (FTLD), frontotemporal dementia (FTD), as a frontostriatal disorder, working towards an endophenotype. METHOD: We provide an overview of the role of frontostriatal circuits relevant to FTLD and FTD, as a subset of larger-scale distributed brain networks. We discuss the role of a strategic structure in these circuits, the neostriatum. Then we review the relationship of the clinical features of FTLD to frontostriatal circuits, correlating this with neuropsychological and neuropathological data. CONCLUSION: The unique structure and linkages of the neostriatum make it an idea..

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Funding Acknowledgements

Research reported here made use of the SMILE medical imaging laboratory at Karolinska University Hospital, Stockholm, Sweden. JCLL was supported by the Canberra Hospital Specialists Private Practice Trust Fund, ACT health funding, and self-funding for travel and accommodation for research conducted at SMILE and Melbourne Neuropsychiatry Centre. The contributions of the volunteers and collaborators of the morphological studies of FTLD conducted at SMILE are also gratefully acknowledged. Collaborators who contributed to the papers on which this review is, in part, based include: Christian Andersen, Lisa Botes, Phyllis Chua, Eva-Lena Engman, Rajeev Kumar, Olof Lindberg, Eva Orndahl, Per Ostberg, Martin Styner, Marc Niethammer, and Bram B. Zandbelt.