Book Chapter

Exercise and Nutritional Interventions to Combat Age-Related Muscle Loss

Rene Koopman, Lex B Verdijk, Luc JC van Loon

SARCOPENIA-AGE-RELATED MUSCLE WASTING AND WEAKNESS: MECHANISMS AND TREATMENTS | SPRINGER-VERLAG BERLIN | Published : 2011

Abstract

Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic diseases such as diabetes. The age-related loss of skeletal muscle mass must be due to a chronic disruption in the balance between muscle protein synthesis and degradation. In addition, it has been suggested that a decline in the number of satellite cells (SC) and/or their ability to become activated can contribute to the development of sarcopenia. In healthy active older individuals, there does not seem to be a disturbance in muscle protein metabolism in the fasted (basal) state. Consequently, it has been proposed t..

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University of Melbourne Researchers