Journal article
Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy
P Kwan, V Wong, PW Ng, CHT Lui, NC Sin, KS Wong, L Baum
Pharmacogenomics | Published : 2011
DOI: 10.2217/pgs.10.183
Abstract
Aim: To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. Results: Genotype distributions of all the selected SNPs were consistent with Hardy-â€"Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug..
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Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China
Funding Acknowledgements
The work described in the paper was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. UHK4466/06M). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.