Journal article
ELF1 is associated with systemic lupus erythematosus in Asian populations
J Yang, W Yang, N Hirankarn, DQ Ye, Y Zhang, HF Pan, CC Mok, TM Chan, RW Sing Wong, MY Mok, KW Lee, SN Wong, AM Ho Leung, XP Li, Y Avihingsanon, P Rianthavorn, T Deekajorndej, K Suphapeetiporn, V Shotelersuk, L Baum Show all
Human Molecular Genetics | Published : 2011
DOI: 10.1093/hmg/ddq474
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 × 10-8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene..
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Awarded by National Natural Science Foundation of China
Funding Acknowledgements
This study was partially supported by the generous donation from Shun Tak District Min Yuen Tong of Hong Kong (to Y.L.L.). W.Y. thanks support from Research Grant Council of the Hong Kong Government (GRF HKU781709M). D.Q.Y. thanks grant support from the key program of National Natural Science Foundation of China (30830089). N.H. and Y.A. thank support from the National Research Council of Thailand; K.S. and V.S. thank supports from Thailand Research Fund. Genotyping of samples serving as controls in this study was supported by Research Grants Council of Hong Kong GRF (HKU 7623/08M, HKU 7747/07M and HKU775608M). Y.Z., S.Z. and J.Z. are supported by Edward Sai-Kim Hotung Paediatric Education and Research Fund and University Postgraduate Studentship.