Journal article
Clinical experience with the treatment of hepatitis C infection in patients on opioid pharmacotherapy
JJ Sasadeusz, G Dore, I Kronborg, D Barton, M Yoshihara, M Weltman
Addiction | Published : 2011
Abstract
Aims To evaluate the efficacy, safety and adherence to hepatitis C (HCV) therapy in patients attending tertiary hepatitis clinics who are receiving opioid replacement therapy. Design A non-randomized, open-label study. Participants were treated with pegylated interferon alpha-2a and weight-based ribavirin for 24 weeks (genotype non-1, n=31) or 48 weeks (genotype 1, n=22). Setting Four tertiary hospital hepatitis clinics in Australia. Participants Fifty-three patients with chronic HCV who were receiving opioid replacement therapy Measurements Patients were monitored for virological response, adverse events and adherence. They were also screened for psychiatric illness prior to and throughout ..
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Funding Acknowledgements
J.S.: advisory boards of Roche, Gilead Sciences; grants: Roche, Gilead Sciences; honoraria: Roche, Gilead Sciences, Bristol Myers Squibb; travel/accommodation: Roche, Gilead Sciences, Schering-Plough Pty. Ltd. G. D.: advisory boards: Roche, Gilead Sciences, Abbott Pharmaceuticals, Merck Sharp and Dohme and Novartis, Bristol Myers Squibb; grants: Roche, Gilead Sciences; honoraria: Roche, Gilead Sciences, Merck Sharp and Dohme and Janssen-Cilag; travel/accommodation: Roche, ScheringPlough Pty. Ltd. I. K.: none. D. B.: none. M.Y.: employee and shareholder of Roche. M. W.: advisory boards: Roche, Novartis and Janssen-Cilag; honoraria: Roche.Study coordinators: Maxine Giourouki, Joanne Patterson, Vincent Fragomelli, Brigita Gregorevic, Marion Croft and Zoe Potgeister. National Centre in HIV Epidemiology and Clinical Research is funded by the Department of Health and Ageing. G. D. is funded by a NHMRC Practitioner Fellowship. The authors thank Roche Products Pty. Ltd, especially Deborah Richards and Dr Scott Bowden, Victorian Infectious Diseases Reference Laboratory for virology support.