Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): A new autosomal dominant syndrome

DL Worthley; KD Phillips; N Wayte; KA Schrader; S Healey; P Kaurah; A Shulkes; F Grimpen; A Clouston; D Moore; D Cullen; D Ormonde; D Mounkley; X Wen; N Lindor; F Carneiro; DG Huntsman; G Chenevix-Trench; GK Suthers

Journal article

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): A new autosomal dominant syndrome

DL Worthley, KD Phillips, N Wayte, KA Schrader, S Healey, P Kaurah, A Shulkes, F Grimpen, A Clouston, D Moore, D Cullen, D Ormonde, D Mounkley, X Wen, N Lindor, F Carneiro, DG Huntsman, G Chenevix-Trench, GK Suthers

Gut | Published : 2012

DOI: 10.1136/gutjnl-2011-300348

Abstract

Objective: The purpose of this study was the clinical and pathological characterisation of a new autosomal dominant gastric polyposis syndrome, gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Methods: Case series were examined, documenting GAPPS in three families from Australia, the USA and Canada. The affected families were identified through referral to centralised clinical genetics centres. Results: The report identifies the clinical and pathological features of this syndrome, including the predominant dysplastic fundic gland polyp histology, the exclusive involvement of the gastric body and fundus, the apparent inverse association with current Helicobacter pylori in..

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