Journal article

Association between canine pancreatic-specific lipase and histologic exocrine pancreatic inflammation in dogs: assessing specificity

Caroline S Mansfield, Garry A Anderson, Amanda J O'Hara

Journal of Veterinary Diagnostic Investigation | SAGE PUBLICATIONS INC | Published : 2012


The current study aimed to determine the specificity, and to a lesser extent the sensitivity, of canine pancreatic-specific lipase (cPL) concentration in dogs with various disease conditions. Dogs were presented for postmortem examination and had serum collected for cPL concentration within 6 hr preceding death or immediately postmortem. Pancreatic tissue was collected postmortem, and sections from the left lobe, right lobe, and body of the pancreas were examined histologically. Inflammation and fibrosis in each section were assessed to determine a total pancreatic inflammatory score and pancreatic fibrosis score in each dog. Correlations between these scores and the cPL concentration were m..

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