Journal article

Cardiac function at term in human pregnancy

Dominica Zentner, Moira du Plessis, Shaun Brennecke, James Wong, Leeanne Grigg, Stephen Harrap

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | ELSEVIER SCI LTD | Published : 2012

Abstract

OBJECTIVES: We have previously demonstrated deterioration in cardiac function at term in human pregnancy. To explore further, we investigated central arterial hemodynamics and association with maternal weight during gestation. STUDY DESIGN: Primiparous women (n=32) were recruited in a tertiary referral obstetric hospital and a longitudinal cohort study with analyses at median 16 and 37weeks gestation undertaken. Subgroups of normal body mass index, <25kg/m(2), and overweight, ⩾25kg/m(2), at 16weeks were created. MAIN OUTCOME MEASURES: We performed 2D speckle tracking echocardiography strain analysis and tonometric measures of central arterial pressures, waveforms and pulse wave velocity. RES..

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Grants

Awarded by National Health and Medical Research Council Postgraduate Medical Scholarship


Funding Acknowledgements

This work was supported by an Australian Postgraduate Award (to D.Z.) and a National Health and Medical Research Council Postgraduate Medical Scholarship {scholarship number 359320 (to D.Z.)}. The funding sources had no involvement on the methodology of the study or its interpretation, in the writing of the manuscript or the decision to submit for publication.