Journal article
A randomized trial of tenecteplase versus alteplase for acute ischemic stroke
M Parsons, N Spratt, A Bivard, B Campbell, K Chung, F Miteff, B O'Brien, C Bladin, P McElduff, C Allen, G Bateman, G Donnan, S Davis, C Levi
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2012
Abstract
BACKGROUND: Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, is an alternative thrombolytic agent. METHODS: In this phase 2B trial, we randomly assigned 75 patients to receive alteplase (0.9 mg per kilogram of body weight) or tenecteplase (0.1 mg per kilogram or 0.25 mg per kilogram) less than 6 hours after the onset of ischemic stroke. To favor the selection of patients most likely to benefit from thrombolytic therapy, the eligibility criteria were a perfusion lesion at least 20% greater than the infarct core on computed tomographic (CT) perfusion imaging at baseline and an associated ..
View full abstractGrants
Funding Acknowledgements
Supported by a grant from the Australian National Health and Medical Research Council.Dr. Parsons reports receiving advisory-board fees from Bayer Australia; Dr. Campbell, consultancy fees from Lundbeck, speaker payments from Boehringer Ingelheim Australia, and grant support from Cardiovascular Lipid Australia; Dr. Bladin, advisory-board fees from Bayer Australia; Dr. Donnan, consultancy fees from Boehringer Ingelheim Australia and Bayer Australia; Dr. Davis, consultancy fees from Orsan Technologies and Ever Pharma; and Dr. Levi, consultancy fees from Boehringer Ingelheim Australia. No other potential conflict of interest relevant to this article was reported.