Journal article
Gold-mediated C-I bond activation of iodobenzene
PSD Robinson, GN Khairallah, G Da Silva, H Lioe, RAJ O'Hair
Angewandte Chemie International Edition | Published : 2012
Abstract
Controversy resolved! A combination of gas-phase ion-molecule reactions and theoretical studies confirm bisligated mononuclear Au I complexes are unable to undergo oxidative addition of iodobenzene for Sonogashira coupling, but that the ligated gold clusters [Au 3L n] + (L=Ph 2P(CH 2) nPPh 2; n=3-6) activate the C-I bond. DFT calculations on the transition states show that the linker size n tunes the cluster reactivity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Grants
Awarded by Australian Research Council (ARC)
Awarded by Australian Research Council
Funding Acknowledgements
We thank the Australian Research Council (ARC) for financial support through DP1096134 and the ARC CoE program, the NCI National Facility at the ANU for the allocation of computing resources under the Merit Allocation Scheme, Prof. Paul Mulvaney for his enthusiastic support of this work, Wen Mike Xiao and Dr. Tich-Lam Nguyen for carrying out preliminary experiments on the synthesis of gold clusters, and Dr. Hudgens for providing preprints on the synthesis of gold clusters.