Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis
Dorothy A Machalek, Mary Poynten, Fengyi Jin, Christopher K Fairley, Annabelle Farnsworth, Suzanne M Garland, Richard J Hillman, Kathy Petoumenos, Jennifer Roberts, Sepehr N Tabrizi, David J Templeton, Andrew E Grulich
LANCET ONCOLOGY | ELSEVIER SCIENCE INC | Published : 2012
BACKGROUND: Men who have sex with men (MSM) are at greatly increased risk of human papillomavirus (HPV)-associated anal cancer. Screening for the presumed cancer precursor, high-grade anal intraepithelial neoplasia (AIN), followed by treatment in a manner analogous to cervical screening, has been proposed. We aimed to assess available data for anal HPV disease that can inform pre-cancer screening programmes. METHODS: We searched PubMed, OVID Medline, and Embase for all studies published before Nov 1, 2011, that reported prevalence and incidence of anal HPV detection, AIN, and anal cancer in MSM. We calculated summary estimates using random-effects meta-analysis. FINDINGS: 53 studies met the ..View full abstract
Awarded by National Health and Medical Research Council
Australian Government Department of Health and Ageing.AEG has received honoraria and research funding from CSL Biotherapies, honoraria and travel funding from Merck, and sits on the Australian advisory board for the Gardasil. CKF has received honoraria, travel funding, and research funding from CSL Biotherapies and MSD, sits on the Australian advisory board for Gardasil HPV vaccine, and owns shares in CSL Biotherapies. SMG has received advisory board fees and grant support from CSL Biotherapies and GlaxoSmithKline, and lecture fees from Merck, GlaxoSmithKline, and Sanofi Pasteur; she has received funding through her institution to do HPV vaccine studies for MSD and GlaxoSmithKline and is a member of the Merck Global Advisory Board and the Merck Scientific Advisory Committee for HPV. RJH has received support from CSL Biotherapies and MSD. All other authors declare that they have no conflicts of interest.The views expressed in this publication do not necessarily represent the position of the Australian Government. The project was supported by National Health and Medical Research Council programme (grant 568971). We thank Anil Chaturvedi, Jonathan Anderson, Gary Clifford, Michael Silverberg, and Isabella Rosa-Cunha for providing stratified data for anal cancer incidence or dysplasia.