Journal article
Markers of vulnerability to obsessive-compulsive disorder in an ultra-high risk sample of patients who developed psychosis
LF Fontenelle, A Lin, C Pantelis, SJ Wood, B Nelson, AR Yung
Early Intervention in Psychiatry | Published : 2012
Abstract
Aims: The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis. Methods: Three hundred and eleven patients at ultra-high risk for psychosis were examined at baseline and after a mean of 7.4years follow-up. Patients who developed psychosis with OCD (PSY+OCD; n=13) and psychosis without OCD (PSY-OCD; n=45) were compared in terms of socio-demographic and clinical features. Results: PSY+OCD patients displayed greater severity of depression before and after conversion to PSY+OCD, and increased rates of depressive disorders before exhibiting PSY+OCD. However, they only displayed greater severity of a..
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Funding Acknowledgements
Associate Professor Leonardo F. Fontenelle was supported by an Endeavour Research Fellowship (postdoctoral research) from the Department of Education, Employment and Workplace Relations (Australia), and Bolsa de Produtividade em Pesquisa, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil); Dr Ashleigh Lin was supported by an NHMRC programme grant; Prof Christos Pantelis was supported by an NHMRC Senior Principal Research Fellowship and NHMRC programme grants; Professor Stephen J. Wood was supported by an NHMRC Clinical Career Development Award and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award; Dr Barnaby Nelson was supported by a Ronald Griffith Fellowship and a NARSAD Young Investigator Award; Prof Alison R. Yung was supported by an NHMRC Senior Research Fellowship.