Journal article

Autoimmunity associated with immunotherapy of cancer

Sally M Amos, Connie PM Duong, Jennifer A Westwood, David S Ritchie, Richard P Junghans, Phillip K Darcy, Michael H Kershaw

BLOOD | AMER SOC HEMATOLOGY | Published : 2011


In this age of promise of new therapies for cancer, immunotherapy is emerging as an exciting treatment option for patients. Vaccines and cytokines are being tested extensively in clinical trials, and strategies using monoclonal antibodies and cell transfer are mediating dramatic regression of tumors in patients with certain malignancies. However, although initially advocated as being more specific for cancer and having fewer side effects than conventional therapies, it is becoming increasingly clear that many immunotherapies can lead to immune reactions against normal tissues. Immunotoxicities resulting from treatment can range from relatively minor conditions, such as skin depigmentation, t..

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Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia, Cancer Council of Victoria, and the Susan G. Komen Breast Cancer Foundation. M. H. K. is supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia. P. K. D. is supported by a National Health and Medical Research Council of Australia Career Development Award. S. M. A. is supported by a Cancer Council of Victoria Postgraduate Cancer Research Scholarship.