Journal article
The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties
R Gugasyan, E Horat, SA Kinkel, F Ross, G Grigoriadis, D Gray, M O'Keeffe, SP Berzins, GT Belz, RJ Grumont, A Banerjee, A Strasser, DI Godfrey, PN Tsichlis, S Gerondakis
EMBO Journal | Published : 2012
Abstract
The role of specific members of the NF-κB family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-κB1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-κB1 regulates multiple events in the thymus that collectively inh..
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Awarded by National Cancer Institute
Funding Acknowledgements
We thank Lorraine O'Reilly, Gayle Davey and Jonathan Coquet for technical advice and assistance. This work was supported by grants from the National Health and Medical Research Council (NHMRC) Australia (R Gugasyan, project grants 356219 and 603713; DG and SPB, Career Development Awards; and GB, DIG, AS and SG NHMRC Fellowships). PNT is supported by NIH grant R01 CA124835. We gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program.