Journal article

T Cell Receptor alpha beta Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection

George C Wang, Pradyot Dash, Jonathan A McCullers, Peter C Doherty, Paul G Thomas

SCIENCE TRANSLATIONAL MEDICINE | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2012

Abstract

A diverse T cell receptor (TCR) repertoire capable of recognizing a broad range of antigenic peptides is thought to be central to effective pathogen-specific immunity by counteracting escape mutations, selecting high-avidity T cells, and providing T cell specificities with comprehensive functional characteristics. However, evidence that TCR diversity is important for the successful control of human infections is limited. A single-cell strategy for the clonotypic analysis of human CD8⁺ TCRαβ repertoires was used to probe the diversity and magnitude of individual human cytomegalovirus (CMV)-specific CD8⁺ T cells recovered directly ex vivo. We found that CD8⁺ TCRαβ repertoire diversity, but not..

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University of Melbourne Researchers

Grants

Awarded by NIH-National Institute of Allergy and Infectious Diseases


Awarded by NIH-National Institute on Aging through Johns Hopkins Older Americans Independence Center


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

Supported by NIH-National Institute of Allergy and Infectious Diseases grants AI70251 (P. C. D.) and AI077714 (P. G. T.); the American Syrian Lebanese Associated Charities (P. C. D. and P. G. T.); NIH-National Institute on Aging grants AG033113 (G. C. W.) and AG021334, through the Johns Hopkins Older Americans Independence Center (G. C. W.); Atlantic Philanthropies, American Geriatrics Society, the John A. Hartford Foundation, and the Association of Subspecialty Professors (T. Franklin Williams Research Scholars Award, G. C. W.); and the Johns Hopkins Biology of Healthy Aging Program (G. C. W.).