Journal article
Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers
M Yan, N Jene, D Byrne, EKA Millar, SA O'Toole, CM McNeil, GJ Bates, AL Harris, AH Banham, RL Sutherland, SB Fox
Breast Cancer Research | BIOMED CENTRAL LTD | Published : 2011
DOI: 10.1186/bcr2869
Open access
Abstract
Introduction: Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg.Methods: Immunoperoxidase staining for FOXP3 and CXCL12 was performed on tissue microarrays from 491 breast cancers. The hypoxia-associated marker carbonic anhydrase IX (CA9) and double FOXP3/CXCR4 staining were performed on sections from a subset of these cancers including 10 basal-like and 11 luminal cancers matched for tumour grade.Results: High Treg infiltration correlated with tumour CXCL12 positivity (OR 1.8..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported in part by the Victorian Breast Cancer Research Consortium, the Victorian Cancer Biobank, Cancer Council Victoria, Cancer Institute of New South Wales, the Australian Cancer Research Foundation, the Petre Foundation, the National Health and Medical Research Council (Project grant 400207 to HX; Project Grants: 535903 and 535947 to EM and RS) and the RT Hall Trust, Australia.