Journal article
Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping
M Agostino, E Yuriev, PA Ramsland
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, due to the large size and high flexibility of these ligands. In this study, we apply our previously developed site mapping technique to investigate the recognition of cancer-related gangliosides by anti-ganglioside antibodies. The results reveal a potential ganglioside-binding motif in the four antibodies studied, suggesting the possibility of structural convergence in the anti-ganglioside immune response. The structural basis of the recognition of ganglioside-mimetic peptide..
View full abstractGrants
Funding Acknowledgements
This research was supported by a small grant from the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, to EY. MA is a recipient of the Monash University Postgraduate Publication Award. PAR is the Sir Zelman Cowen Senior Research Fellow (Sir Zelman Cowen Fellowship Fund, Burnet Institute). The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.