Journal article

Prolonged Survival of Allogeneic Islets in Cynomolgus Monkeys After Short-Term Triple Therapy

M Koulmanda, A Qipo, Z Fan, N Smith, H Auchincloss, XX Zheng, TB Strom

AMERICAN JOURNAL OF TRANSPLANTATION | WILEY-BLACKWELL | Published : 2012

Abstract

Preclinical studies in nonhuman primates (NHP) are particularly useful to evaluate the safety and efficacy of new therapeutic proteins developed for use in clinical transplantation. We hypothesized that a treatment that selectively destroys activated cytopathic donor reactive T cells while sparing resting and immunoregulatory T cells in a mouse model might also produce long-term drug-free engraftment and tolerance without the hazards of lymphopenia in the challenging nonhuman primate islet allograft model. Short-term treatment with a regimen consisting of rapamycin, and IL-2.Ig plus mutant antagonist-type IL-15.Ig cytolytic fusion proteins (triple therapy) posttransplantation results in prol..

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University of Melbourne Researchers

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Awarded by NIH


Awarded by Medical Research Council


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

We thank Vaja Tchipashivili from the Joslin Diabetes Center for providing monkey islets and Luba Zachachin for expert assistance with tissue processing. This work was funded in part by the NIH PO1 DK53087 and the Juvenile Diabetes Research Foundation Center for Islet Transplantation at Harvard Medical School.