Journal article
Wnt signalling pathway parameters for mammalian cells
CW Tan, BS Gardiner, Y Hirokawa, MJ Layton, DW Smith, AW Burgess
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Open access
Abstract
Wnt/β-catenin signalling regulates cell fate, survival, proliferation and differentiation at many stages of mammalian development and pathology. Mutations of two key proteins in the pathway, APC and β-catenin, have been implicated in a range of cancers, including colorectal cancer. Activation of Wnt signalling has been associated with the stabilization and nuclear accumulation of β-catenin and consequential up-regulation of β-catenin/TCF gene transcription. In 2003, Lee et al. constructed a computational model of Wnt signalling supported by experimental data from analysis of time-dependent concentration of Wnt signalling proteins in Xenopus egg extracts. Subsequent studies have used the Xeno..
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Awarded by Ludwig Institute for Cancer Research
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council (NHMRC) Project Grant 542531 "Wnt signalling in colon cancer'', Program Grant 487922 "Colorectal cancer - molecular basis to targeted therapeutics'', and by funds from the Operational Infrastructure Support Program provided by the Victorian Government, Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Additionally the manuscript is solely the responsibility of the institutions and individual authors and does not reflect the views of NHMRC.