Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study
Darren M Roberts, Jason A Roberts, Michael S Roberts, Xin Liu, Priya Nair, Louise Cole, Jeffrey Lipman, Rinaldo Bellomo
CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
OBJECTIVES: In critically ill patients receiving continuous renal replacement therapy, we aimed to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates on such concentrations, and the incidence of suboptimal antibiotic dosage. DESIGN: Prospective, observational, multicenter, pharmacokinetic study. SETTING: Four tertiary intensive care units within the multicenter RENAL randomized controlled trial of continuous renal replacement therapy intensity. PATIENTS: Twenty-four critically ill adult patients with acute kidney injury receiving ciprofloxacin, meropenem, piperacillin/tazobactam, or vancomycin during continuous renal replacement therapy. INTERVEN..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by Health Research Council of New Zealand
Supported, in part, by grants from the National Health and Medical Research Council of Australia (352550) and the Health Research Council of New Zealand (06-357).Dr. Jason A. Roberts consulted for AstraZeneca and Janssen-Cilag; received honoraria from Pfizer and AstraZeneca; and received grant support from AstraZeneca, Janssen-Cilag, and Novartis. Dr. Lipman consulted for Janssen-Cilag and MSD; received honoraria from Janssen-Cilag and AstraZeneca; and received grant support from AstraZeneca. The remaining authors have not disclosed any potential conflicts of interest.