Journal article

The Role of TNF-alpha in Mice with Type 1-and 2-Diabetes

Maria Koulmanda, Manoj Bhasin, Zuheir Awdeh, Andi Qipo, Zhigang Fan, Dusan Hanidziar, Prabhakar Putheti, Hang Shi, Eva Csizuadia, Towia A Libermann, Terry B Strom

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

BACKGROUND: Previously, we have demonstrated that short-term treatment of new onset diabetic Non-obese diabetic (NOD) mice, mice that are afflicted with both type 1 (T1D) and type 2 (T2D) diabetes with either Power Mix (PM) regimen or alpha1 antitrypsin (AAT) permanently restores euglycemia, immune tolerance to self-islets and normal insulin signaling. METHODOLOGY AND PRINCIPAL FINDINGS: To search for relevant therapeutic targets, we have applied genome wide transcriptional profiling and systems biology oriented bioinformatics analysis to examine the impact of the PM and AAT regimens upon pancreatic lymph node (PLN) and fat, a crucial tissue for insulin dependent glucose disposal, in new ons..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health (NIH)


Awarded by Medical Research Council


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

This work was funded both by the Juvenile Diabetes Research Foundation and National Institutes of Health (NIH). Juvenile Diabetes Research Foundation: TS, MK, ZF: JDRF 402004-368 NIH: MK, BH, AQ: NIH RO1 AI54976; MK, TS: NIH RO1 DK067632: TS, PP: NIH PO1 AI041521; JSF, HS: NIH NIH R37 DK 28082: SBW: NIH DK44523 and DK 66056. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.