Journal article

Foxp3( ) T cells in peripheral blood of renal transplant recipients and clinical correlations

Wen X Lin, Dale Christiansen, Lu L Fu, Matthew A Roberts, Mauro S Sandrin, Francesco L Ierino

NEPHROLOGY | WILEY | Published : 2012

Abstract

AIM: Immunophenotype peripheral blood T cells from renal transplant recipients (RTR) using cellular markers of regulatory T cells (Tregs) and flow cytometry, including Foxp3, and correlate these findings with clinical parameters. METHODS: Expression of phenotypic markers of Tregs was assessed by flow cytometric analysis of peripheral blood lymphocytes (PBL) from (i) RTR (n = 95); (ii) patients with end-stage renal failure (ESRF) awaiting transplantation (n = 17); and (iii) normal healthy controls (n = 18). RESULTS: The percentage of CD4(+) CD25(+) Foxp3(+) cells within the CD4(+) cell population did not significantly alter at different time points post-transplant. However, the percentage of ..

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University of Melbourne Researchers