Journal article
N-terminal pro-brain natriuretic peptide and angiotensin-converting enzyme-2 levels and their association with postoperative cardiac complications after emergency orthopedic surgery
CP Chong, WK Lim, E Velkoska, WJ Van Gaal, JE Ryan, J Savige, LM Burrell
American Journal of Cardiology | Published : 2012
Abstract
The prognostic usefulness of the cardiac biomarkers N-terminal pro-brain natriuretic peptide (NT-proBNP) and angiotensin-converting enzyme 2 (ACE-2), in predicting adverse cardiac outcomes after orthopedic surgery is not well studied. The aim of our study was to determine the usefulness of perioperative NT-proBNP and ACE-2 for predicting cardiac events after emergency orthopedic surgery. The perioperative NT-proBNP and ACE-2 levels were determined in 187 consecutive patients aged >60 years who underwent orthopedic surgery with 1 year of follow-up for any cardiac complications (defined as acute myocardial infarction, congestive cardiac failure, atrial fibrillation, or major arrhythmia) and de..
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Funding Acknowledgements
This study was sponsored by a Cardiovascular Lipid grant 2009 from Pfizer, Australia (West Ryde, Australia). Dr. Chong is a recipient of a National Health and Medical Research Council (Canberra, ACT, Australia) postgraduate research scholarship and has received research stipends from the University of Melbourne (Melbourne, Victoria, Australia) and the Northern Clinical Research Centre, Northern Health (Epping, Victoria, Australia).