Gluconeogenesis

Abstract

The major pathways of carbon metabolism are glycolytic breakdown of sugars and the tricarboxylic acid (TCA) cycle for energy generation and the synthesis of biosynthetic intermediates. Growth on carbon compounds metabolized via TCA cycle intermediates requires the net formation of sugars from TCA cycle intermediates in the process of gluconeogenesis-a reversal of glycolysis, in which TCA cycle intermediates are converted to sugars. It is likely that mycelia undergoing carbon starvation in the wild are common, and survival depends on the breakdown of cellular components resulting in carbon sources requiring gluconeogenesis. In asexual spores, mRNAs for gluconeogenic, glyoxylate cycle, and ß-o..