Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis

Abstract

Purpose: We determined the role of factor inhibiting hypoxia-inducible factor-1 in prostate cancer specimens. Materials and Methods: A tissue microarray of 152 prostate cancers was constructed and stained for factor inhibiting hypoxia-inducible factor-1, hypoxia-inducible factor-1α and 2α, and glucose transporter 1 as a prototypical downstream target of hypoxia-inducible factor-1α. Correlation analysis was done between these variables, and between factor inhibiting hypoxia-inducible factor-1, and clinical and pathological variables, including prostate specific antigen as a surrogate of recurrence. Results: Factor inhibiting hypoxia-inducible factor-1 was expressed in the cytoplasm and/or the..