Journal article

Whole-genome sequence of Schistosoma haematobium

Neil D Young, Aaron R Jex, Bo Li, Shiping Liu, Linfeng Yang, Zijun Xiong, Yingrui Li, Cinzia Cantacessi, Ross S Hall, Xun Xu, Fangyuan Chen, Xuan Wu, Adhemar Zerlotini, Guilherme Oliveira, Andreas Hofmann, Guojie Zhang, Xiaodong Fang, Yi Kang, Bronwyn E Campbell, Alex Loukas Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2012

Abstract

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based te..

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Grants

Awarded by Liang of the Biomedical Research Institute, under NIAID-NIH


Awarded by NIH-Fogarty


Awarded by FAPEMIG


Awarded by CNPq


Awarded by FOGARTY INTERNATIONAL CENTER


Funding Acknowledgements

This project was funded by the Australian Research Council (R.B.G. and H.M.Y.) and BGI. We are grateful for other support from the National Health and Medical Research Council (NHMRC) of Australia (R.B.G.), the Australian Academy of Science, the Australian-American Fulbright Commission, Melbourne Water Corporation, the Victorian Life Sciences Computation Initiative (VLSCI) and the IBM Collaboratory. N.D.Y. (Early Career Research Fellow) and A.R.J. (CDA1 Fellow) were supported by NHMRC fellowships. We thank staff of BGI-Shenzhen, including Q. Nan, P. Na, B. Min and P. Ni for their contributions. Schistosoma haematobium-infected hamsters were provided by F.A. Lewis and Y.-S. Liang of the Biomedical Research Institute, under NIAID-NIH contract HHSN272201000005I. G.O. is supported by NIH-Fogarty TW007012, FAPEMIG CBB-1181/08 and CNPq 573839/2008-5.