Journal article
The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
SK Patel, B Wai, RJ MacIsaac, S Grant, E Velkoska, M Ord, S Panagiotopoulos, G Jerums, PM Srivastava, LM Burrell
Cardiovascular Diabetology | BMC | Published : 2012
Abstract
Background: Connective tissue growth factor (CTGF) has been implicated in the cardiac and kidney complications of type 2 diabetes, and the CTGF -945 G/C polymorphism is associated with susceptibility to systemic sclerosis, a disease characterised by tissue fibrosis. This study investigated the association of the CTGF -945 G/C promoter variant with cardiac complications (left ventricular (LV) hypertrophy (LVH), diastolic and systolic dysfunction) and chronic kidney disease (CKD) in type 2 diabetes.Methods: The CTGF -945 G/C polymorphism (rs6918698) was examined in 495 Caucasian subjects with type 2 diabetes. Cardiac structure and function were assessed by transthoracic echocardiography. Kidne..
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Funding Acknowledgements
This study was undertaken with the support of the National Health and Medical Research Council (NHMRC), Australia. S. K. P was supported by an Early Career Researcher Grant, University of Melbourne; B. W was supported by an NHMRC and National Heart Foundation scholarship award. We thank the sonographers who performed the echocardiograms and the individuals who participated in this study.