Journal article
Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: A voxelwise PiB-PET longitudinal study
N Villain, G Chételat, B Grassiot, P Bourgeat, G Jones, KA Ellis, D Ames, RN Martins, F Eustache, O Salvado, CL Masters, CC Rowe, VL Villemagne
Brain | Published : 2012
DOI: 10.1093/brain/aws125
Abstract
Amyloid-β deposition in Alzheimer's disease is thought to start while individuals are still cognitively unimpaired and it is hypothesized that after an early phase of fast accumulation, a plateau is reached by the time of cognitive decline. However, few longitudinal Pittsburgh compound B-positron emission tomography studies have tested this hypothesis, and with conflicting results. The purpose of this work is to further our understanding of the dynamics of amyloid-b deposition in a large longitudinal cohort. A total of 32 patients with Alzheimer's disease, 49 subjects with mild cognitive impairment and 103 healthy controls underwent two Pittsburgh compound B-positron emission tomography scan..
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Funding Acknowledgements
Servier Institute (N.V. and B.G., partial); Inserm-Liliane Bettencourt MD-PhD Program (N.V., partial); Commonwealth Scientific Industrial Research Organization Preventative Health Flagship Program through the Australian Imaging, Biomarkers and Lifestyle flagship study of aging (AIBL) and Austin Hospital Medical Research Foundation, Neurosciences Victoria and the University of Melbourne. The funding sources had no input into the design of this study, the analysis of data or writing of the manuscript.