Journal article
The heritability of brain metabolites on proton magnetic resonance spectroscopy in older individuals
SAH Batouli, PS Sachdev, W Wen, MJ Wright, C Suo, D Ames, JN Trollor
Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2012
Abstract
Twin studies have shown that many aspects of brain structure are heritable, suggesting a strong genetic contribution to brain structure. Less is known about functional aspects of the brain, in particular biologically relevant metabolites in the brain such as those measured by proton magnetic resonance spectroscopy ( 1H MRS), N-acetyl-aspartate (NAA), creatine (Cr), choline (Cho) and myoinositol (ml), which have been suggested as possible markers of brain aging and early dementia. We examined 296 (56 male/108 female monozygotic and 43 male/89 female dizygotic) older twins (mean age 72.2±5.5years, range 65-88), for the levels of these metabolites relative to the H 2O signal in the posterior ci..
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Funding Acknowledgements
This study was supported by an NHMRC/ARC Strategic Award Grant of the Ageing Well, Ageing Productively Program (ID No. 401126), and facilitated with access to the Australian Twin Registry. We thank all current and past OATS staff members for their contributions to study planning, data acquisition and analysis, especially the following individuals: New South Wales (Pamela Azar, Henry Brodaty, Tanya Duckworth, Kristan Kang, Fiona Kumfor, Andrea Lammel, Alissa Nichles, Peter Schofield, Alison Walker, Shaily Aggarwal, Caroline Arasartnam), Queensland (Mark Strudwick, Katie McMahon, Harry Beeby, Anthony Caracella, Natalie Garden, Anjali Henders, Nick Martin, Clare Redfern, Amanda Toivanen), and Victoria (Nicholas Cortes, Karla Elliott, Christel Lemmon, Simone Mangelsdorf, Gihan de Mel, Tabitha Nash, Stacey Walker, Alex Connelly). Kate Crosbie assisted with manuscript preparation. We also would like to specially thank Dr. John Crawford for his assistance in statistical analyses.