Journal article
Rational use of trastuzumab in metastatic and locally advanced breast cancer: Implications of recent research
S Goel, J Chirgwin, P Francis, R Stuart-Harris, J Dewar, L Mileshkin, R Snyder, M Michael, B Koczwara
Breast | CHURCHILL LIVINGSTONE | Published : 2011
Abstract
The management of HER2-positive metastatic breast cancer, a disease renowned for its aggressive natural history, has been revolutionized by the introduction of trastuzumab. Indeed, outcomes for patients with HER2-positive advanced breast cancer are now equivalent to, if not better than, those of their HER2-negative counterparts. Since the pivotal registration trial, a wealth of new clinical data has emerged regarding the use of trastuzumab in a variety of clinical contexts - adding to the evidence but also highlighting areas of uncertainly and debate. These include the optimal partner chemotherapy(ies) to trastuzumab; the effectiveness of combining trastuzumab with endocrine therapy; the ben..
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Funding Acknowledgements
Dr Chirgwin has received conference travel support from Roche, GlaxoSmithKline, Sanofi Aventis, Schering Plough, and AstraZeneca, and has served on advisory boards for Hospira, Amgen, Novartis, and AstraZeneca; Dr Dewar has received conference travel support from Roche and GlaxoSmithKline; Dr Francis has received conference travel support from Roche, GlaxoSmithKline, Lilly, and Sanofi-Aventis; Dr Goel has received conference travel support from Roche, GlaxoSmithKline, Lilly, and Pfizer; Dr Koczwara has received research support from Roche and GlaxoSmithKline; Dr Snyder has served on advisory boards for Roche and GlaxoSmithKline; Michael, M., Mileshkin, L, Stuart-Harris, R.: None,