Journal article
Risk factors for relapse following treatment for first episode psychosis: A systematic review and meta-analysis of longitudinal studies
M Alvarez-Jimenez, A Priede, SE Hetrick, S Bendall, E Killackey, AG Parker, PD McGorry, JF Gleeson
Schizophrenia Research | ELSEVIER | Published : 2012
Abstract
Background: Preventing relapse is an essential element of early intervention in psychosis, but relevant risk factors and precise relapse rates remain to be clarified. The aim of this study was to systematically compile and analyse risk factors for and rates of relapse in the early course of psychosis. Methods: Systematic review and meta-analysis of English and non-English language, peer-reviewed, longitudinal studies, with a minimum 12-month follow-up and at least 80% of participants diagnosed with a first episode of psychosis (FEP) that reported risk factors for relapse. Results: Of 153 potentially relevant articles, 29 were included in the study. Pooled prevalence of relapse of positive sy..
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Funding Acknowledgements
This study was supported by generous funding from the Colonial Foundation to Orygen Youth Health Research Centre. Furthermore, support was provided by Marques de Valdecilla Public Foundation-Research Institute, Santander, Spain (Dr Priede). The sponsors did not participate in the design or conduct of this study; in the collection, management, analysis, or interpretation of data; in the writing of the manuscript; or in the preparation, review, approval, or decision to submit this manuscript for publication.