Journal article
Metal-free and MRI visible theranostic lyotropic liquid crystal nitroxide-based nanoparticles
BW Muir, DP Acharya, DF Kennedy, X Mulet, RA Evans, SM Pereira, KL Wark, BJ Boyd, TH Nguyen, TM Hinton, LJ Waddington, N Kirby, DK Wright, HX Wang, GF Egan, BA Moffat
Biomaterials | Published : 2012
Abstract
The development of improved, low toxicity, clinically viable nanomaterials that provide MRI contrast have tremendous potential to form the basis of translatable theranostic agents. Herein we describe a class of MRI visible materials based on lyotropic liquid crystal nanoparticles loaded with a paramagnetic nitroxide lipid. These readily synthesized nanoparticles achieved enhanced proton-relaxivities on the order of clinically used gadolinium complexes such as Omniscan™ without the use of heavy metal coordination complexes. Their low toxicity, high water solubility and colloidal stability in buffer resulted in them being well tolerated invitro and invivo. The nanoparticles were initially scre..
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Awarded by British Academy of Management
Funding Acknowledgements
The authors would like to acknowledge the work of Charles River Discovery and Imaging Services for performing MID testing and in particular Vinod Kaimal, Patrick McConville and Lisa Repke. The authors would also like to thank Charlotte Conn for useful discussions and calculations on the size of the continuous water channels in the cubic phase nanoparticles and Adrian Hawley for help with SAXS analysis. This research was undertaken on the SAXS/WAXS beamline at the Australian Synchrotron, Victoria, Australia. This work was supported by Australian NHMRC Fellowships to GFE (#1003993) and BAM (#454790).