CD73: a potent suppressor of antitumor immune responses
Paul A Beavis, John Stagg, Phillip K Darcy, Mark J Smyth
TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2012
Tumors use several strategies to evade immunosurveillance. One such mechanism is the generation of adenosine within the tumor microenvironment, which potently suppresses antitumor T cell responses. Adenosine within the tumor is generated by CD73, a membrane-bound nucleotidase that is expressed by tumor cells, suppressive immune subsets such as T regulatory cells (Tregs) and myeloid-derived suppressor cells and endothelial cells. Recent evidence suggests that targeted inhibition of CD73 has the potential to reduce tumorigenesis and metastasis, as well as enhancing the potency of T-cell-directed therapies. This review outlines the impact of adenosine on suppressing the antitumor response and t..View full abstract
The authors wish to acknowledge the technical support of Upulie Divisekera. All authors were supported by the National Health and Medical Research Council (NH&MRC) of Australia, in the form of NH&MRC Project Grant, Australia Fellowship and CDA2 awards. MJS was also supported by the Victorian Breast Cancer Consortium and Victorian Cancer Agency.