Journal article

CD73: a potent suppressor of antitumor immune responses

Paul A Beavis, John Stagg, Phillip K Darcy, Mark J Smyth

TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2012

Abstract

Tumors use several strategies to evade immunosurveillance. One such mechanism is the generation of adenosine within the tumor microenvironment, which potently suppresses antitumor T cell responses. Adenosine within the tumor is generated by CD73, a membrane-bound nucleotidase that is expressed by tumor cells, suppressive immune subsets such as T regulatory cells (Tregs) and myeloid-derived suppressor cells and endothelial cells. Recent evidence suggests that targeted inhibition of CD73 has the potential to reduce tumorigenesis and metastasis, as well as enhancing the potency of T-cell-directed therapies. This review outlines the impact of adenosine on suppressing the antitumor response and t..

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Grants

Funding Acknowledgements

The authors wish to acknowledge the technical support of Upulie Divisekera. All authors were supported by the National Health and Medical Research Council (NH&MRC) of Australia, in the form of NH&MRC Project Grant, Australia Fellowship and CDA2 awards. MJS was also supported by the Victorian Breast Cancer Consortium and Victorian Cancer Agency.