Journal article
Lower back-up rates improve ventilator triggering during assist-control ventilation: A randomized crossover trial
KI Wheeler, CJ Morley, SB Hooper, PG Davis
Journal of Perinatology | Published : 2012
DOI: 10.1038/jp.2011.73
Abstract
Objective:The objective of this study is to compare the effects of back-up ventilation rates (BURs) on triggered inflations and patient cardiorespiratory stability during assist-control/volume guarantee ventilation (AC/VG). Study Design:This study is a randomized crossover trial conducted in a neonatal unit in an Australian tertiary NICU. In all, 26 stable preterm infants on AC/VG ventilation were studied at BUR settings of 30, 40 and 50 min -1. Inflation rate, triggering and cardiorespiratory measures of patient stability were compared during 20 min epochs with 10 min washout periods. Result:The 26 infants studied were median (inter-quartile range) gestational age 27 (26, 30) weeks, birth w..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We acknowledge the participation of the patients and their families and the support of the nursing staff at the Royal Women's Hospital. Connie Wong provided assistance with recruitment and data collection. Professor Stuart Hooper provided assistance with preparation of the manuscript. We are grateful to Professor Martin Keszler for his suggestions regarding using lower bark-up rates, Dr Paul Dixon for providing advice regarding data acquisition and processing, and A/Professor Susan Donath for methodological and statistical advice. KIW is supported by the Monash University International Graduate Scholarship. This project was funded by Australian National Health and Medical Research Council grant #384100. Peter Davis and Stuart Hooper are in receipt of Australian National Health and Medical Research Council research fellowships.