Journal article
Increasing age at disability milestones among MS patients in the MSBase Registry
I Kister, E Chamot, G Cutter, TE Bacon, VG Jokubaitis, SE Hughes, OM Gray, M Trojano, G Izquierdo, F Grand'Maison, P Duquette, A Lugaresi, P Grammond, C Boz, R Hupperts, T Petersen, G Giuliani, C Oreja-Guevara, G Iuliano, J Lechner-Scott Show all
Journal of the Neurological Sciences | ELSEVIER SCIENCE BV | Published : 2012
Abstract
Objective: To analyze time-trends in age at disability milestones among MS patients who were enrolled into the MSBase International Registry during 1996-2010 period. Methods: We used linear regression to describe the relationship between mean age at major EDSS benchmarks and calendar time. We then assessed time-trend in age at initial EDSS rating with a three level linear growth model specifying that patients were nested within each of 20 participating countries. The model estimated the average of time-trends in mean age at initial clinical assessment within each country while controlling for patients' EDSS and sex in each country. Analyses were repeated in subsamples of patients diagnosed a..
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Funding Acknowledgements
MSBase International Registry is sponsored by the MSBase Foundation, a not-for-profit organization. The MSBase Foundation receives financial support from Merck Serono, Biogen Idec, Novartis Pharma, Bayer Schering and Sanofi. The study was carried out using authors' own resources.