Selected changes in spinal cord morphology after T4 transection and olfactory ensheathing cell transplantation
Tomas Kalincik, Katarina Jozefcikova, Ratneswary Sutharsan, Alan Mackay-Sim, Pascal Carrive, Phil ME Waite
Autonomic Neuroscience - Basic & Clinical | ELSEVIER SCIENCE BV | Published : 2010
Spinal cord transection at T4 results in severe damage of the nervous tissue, with impairment of motor, sensory and autonomic functions. Transplantation of olfactory ensheathing cells (OECs) has the potential to improve these functions through a number of mechanisms, which include facilitation of regeneration and neuroprotection. For cardiovascular functions, we have previously shown that OECs reduce the duration of autonomic dysreflexia, without evidence of regeneration. To further understand the mechanisms underpinning this improvement, we have studied changes in selected morphological features (cavitation, non-cavity tissue loss, morphology of sympathetic preganglionic neurons and primary..View full abstract
This research was supported by an International Spinal Research Trust grant Authors would like to thank Dr Cathy Gorrie for her advice on the methodology of the studies Mr Colm Cahill for coordinating the supply of OECs at later stages of the experimental work and Ms Linda Larsen and Mr Vijayaganapathy Vaithilingam for technical support.