Journal article

Identification of Label-Retaining Perivascular Cells in a Mouse Model of Endometrial Decidualization, Breakdown, and Repair

Tu'uhevaha J Kaitu'u-Lino, Louie Ye, Lois A Salamonsen, Jane E Girling, Caroline E Gargett

BIOLOGY OF REPRODUCTION | OXFORD UNIV PRESS INC | Published : 2012

Abstract

The human endometrium is incredibly dynamic, undergoing monthly cycles of growth and regression during a woman's reproductive life. Endometrial repair at the cessation of menstruation is critical for reestablishment of a functional endometrium receptive for embryo implantation; however, little is understood about the mechanisms behind this rapid and highly efficient process. This study utilized a functional mouse model of endometrial breakdown and repair to assess changes in endometrial vasculature that accompany these dynamic processes. Given that adult endometrial stem/progenitor cells identified in human and mouse endometrium are likely contributors to the remarkable regenerative capacity..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

Supported by the National Health and Medical Research Council of Australia (ID 490995 to T.J.K., ID 465121 to C.E.G., ID 545992 to C.E.G.), Royal Australian and New Zealand College of Obstetricians and Gynaecologists (to T.J.K.), Monash University, and the Victorian Government's Operational Infrastructure Support Program.