tkt1, located on a novel pathogenicity island, is prevalent in avian and human extraintestinal pathogenic Escherichia coli
Ganwu Li, Subhashinie Kariyawasam, Kelly A Tivendale, Yvonne Wannemuehler, Christa Ewers, Lothar H Wieler, Catherine M Logue, Lisa K Nolan
BMC Microbiology | BIOMED CENTRAL LTD | Published : 2012
BACKGROUND: Extraintestinal pathogenic Escherichia coli are important pathogens of human and animal hosts. Some human and avian extraintestinal pathogenic E. coli are indistinguishable on the basis of diseases caused, multilocus sequence and phylogenetic typing, carriage of large virulence plasmids and traits known to be associated with extraintestinal pathogenic E. coli virulence. RESULTS: The gene tkt1 identified by a previous signature-tagged transposon mutagenesis study, was found on a 16-kb genomic island of avian pathogenic Escherichia coli (APEC) O1, the first pathogenic Escherichia coli strain whose genome has been completely sequenced. tkt1 was present in 39.6% (38/96) of pathogenic..View full abstract
Awarded by USDA NRICGP
This work was supported by USDA NRICGP Microbial Functional Genomics Program (20083560418805).